| Name | What | Region | Country | Lat | Long | Elev ft. | Pop est |
|---|---|---|---|---|---|---|---|
| Spica | city | Kansas | United States | 39.21 | -100.92 | 3349 | |
| Spice | city | West Virginia | United States | 38.11 | -80.27 | 2723 | |
| Spice Knob | city | Kentucky | United States | 37.82 | -86.97 | 830 | |
| Spiceland | city | Indiana | United States | 39.84 | -85.44 | 1076 | |
| Spicer | city | Minnesota | United States | 45.23 | -94.94 | 1161 | |
| Spicer City | city | California | United States | 35.50 | -119.60 | 328 | |
| Spicertown | city | New Jersey | United States | 40.91 | -74.58 | 830 | |
| Spicewood | city | North Carolina | United States | 36.13 | -79.79 | 830 | |
| Spicewood | city | Texas | United States | 30.48 | -98.16 | 830 | |
| Spicewood Acres | city | North Carolina | United States | 35.18 | -80.70 | 830 | |
| Spickard | city | Missouri | United States | 40.24 | -93.59 | 830 | |
| Spickler | city | Maryland | United States | 39.66 | -77.87 | 830 | |
| Spider | city | Kentucky | United States | 37.26 | -82.91 | 1669 | |
| Spider (historical) | city | Louisiana | United States | 31.95 | -93.78 | 324 | |
| Spiderweb | city | South Carolina | United States | 33.41 | -81.83 | 344 | |
| Spielerville (historical) | city | Arkansas | United States | 35.31 | -93.64 | 830 | |
| Spielman | city | Maryland | United States | 39.54 | -77.76 | 830 | |
| Spier Pines | city | New York | United States | 43.25 | -73.69 | 328 | |
| Spies | city | North Carolina | United States | 35.42 | -79.67 | 830 | |
| Spiess | city | New Mexico | United States | 35.46 | -105.91 | 6709 | |
| Spiess Trailer Park | city | Ohio | United States | 41.45 | -84.00 | 830 | |
| Spike | city | Kentucky | United States | 37.41 | -86.08 | 830 | |
| Spike Island | city | Pennsylvania | United States | 40.84 | -78.27 | 1669 | |
| Spike Island | city | Pennsylvania | United States | 41.35 | -75.72 | 830 | |
| Spikenard (historical) | city | Oregon | United States | 42.61 | -122.95 | 1797 | |
| Spile | city | Georgia | United States | 34.93 | -83.98 | 2070 | |
| Spillcorn | city | North Carolina | United States | 35.95 | -82.65 | 2864 | |
| Spiller | city | Ohio | United States | 38.99 | -81.84 | 830 | |
| Spillers | city | Florida | United States | 27.97 | -82.38 | 9 | |
| Spillers Store | city | Texas | United States | 31.14 | -95.87 | 252 | |
| Spillertown | city | Illinois | United States | 37.77 | -88.92 | 830 | |
| Spillman | city | Louisiana | United States | 30.93 | -91.28 | 249 | |
| Spillville | city | Iowa | United States | 43.20 | -91.95 | 1099 | |
| Spilo (historical) | city | Georgia | United States | 34.93 | -83.98 | 2070 | |
| Spilona | city | North Carolina | United States | 35.49 | -78.47 | 249 | |
| Spilt Rock | city | Pennsylvania | United States | 41.06 | -75.61 | 1899 | |
| Spindale | city | North Carolina | United States | 35.36 | -81.93 | 1079 | |
| Spindletop | city | Texas | United States | 30.03 | -94.06 | 22 | |
| Spindletop Estates | city | Kentucky | United States | 38.13 | -84.52 | 898 | |
| Spindletown | city | Pennsylvania | United States | 40.99 | -78.93 | 1669 | |
| Spindleville | city | Massachusetts | United States | 42.11 | -71.53 | 236 | |
| Spindley City | city | Pennsylvania | United States | 40.54 | -78.57 | 1889 | |
| Spink | city | Idaho | United States | 44.79 | -116.05 | 5029 | |
| Spink | city | South Dakota | United States | 42.85 | -96.75 | 1227 | |
| Spink Colony | city | South Dakota | United States | 44.75 | -98.29 | 1669 | |
| Spinks | city | Alabama | United States | 32.76 | -85.62 | 830 | |
| Spinks (historical) | city | Mississippi | United States | 32.71 | -88.89 | 830 | |
| Spinks Corner | city | California | United States | 36.21 | -119.23 | 305 | |
| Spinks Corners | city | Michigan | United States | 42.09 | -86.32 | 830 | |
| Spinnerstown | city | Pennsylvania | United States | 40.44 | -75.44 | 830 | |
| Spinnerville | city | New York | United States | 42.97 | -75.04 | 1669 | |
| Spio (historical) | city | Alabama | United States | 31.70 | -85.42 | 830 | |
| Spion Kop | city | Montana | United States | 47.28 | -110.62 | 4399 | |
| Spires | city | Illinois | United States | 40.88 | -88.96 | 830 | |
| Spirit | city | Washington | United States | 48.83 | -117.65 | 1998 | |
| Spirit | city | Wisconsin | United States | 45.45 | -90.11 | 1669 | |
| Spirit Falls | city | Wisconsin | United States | 45.45 | -89.98 | 1669 | |
| Spirit Lake | city | Idaho | United States | 47.97 | -116.87 | 2611 | |
| Spirit Lake | city | Iowa | United States | 43.42 | -95.10 | 1669 | |
| Spiritwood | city | North Dakota | United States | 46.94 | -98.50 | 1669 | |
| Spiritwood Lake | city | North Dakota | United States | 47.08 | -98.57 | 1669 | |
| Spirk Mobile Home Park | city | Ohio | United States | 40.37 | -84.37 | 948 | |
| Spiro | city | Kentucky | United States | 37.34 | -84.40 | 1145 | |
| Spiro | city | Oklahoma | United States | 35.24 | -94.62 | 830 | |
| Spiry Place | city | Idaho | United States | 42.91 | -116.41 | 3398 | |
| Spitler Park | city | Florida | United States | 27.87 | -82.50 | 6 | |
| Spitzenberg | city | Oregon | United States | 45.83 | -122.95 | 830 | |
| Spivak | city | Colorado | United States | 39.74 | -105.07 | 5370 | |
| Spivey | city | Florida | United States | 28.07 | -82.57 | 29 | |
| Spivey | city | Kansas | United States | 37.45 | -98.16 | 1669 | |
| Spivey | city | Tennessee | United States | 36.60 | -85.83 | 895 | |
| Spivey (historical) | city | Georgia | United States | 33.40 | -83.27 | 830 | |
| Spivey Acres | city | Florida | United States | 28.08 | -82.21 | 72 | |
| Spivey Chase | city | Georgia | United States | 33.50 | -84.26 | 830 | |
| Spivey Crossing | city | Texas | United States | 31.79 | -97.32 | 830 | |
| Spivey Mill | city | Virginia | United States | 36.66 | -82.66 | 1669 | |
| Spivey Miller | city | Florida | United States | 27.92 | -82.38 | 9 | |
| Spivey Road | city | Florida | United States | 27.84 | -82.36 | 19 | |
| Spivey Store | city | Virginia | United States | 36.70 | -82.68 | 1233 | |
| Spiveys Corner | city | North Carolina | United States | 35.20 | -78.49 | 200 |