| Name | What | Region | Country | Lat | Long | Elev ft. | Pop est |
|---|---|---|---|---|---|---|---|
| Spangler | city | West Virginia | United States | 38.61 | -80.02 | 2509 | |
| Spangler | city | West Virginia | United States | 38.30 | -81.29 | 1669 | |
| Spangler Factory (historical) | city | West Virginia | United States | 37.74 | -81.19 | 2509 | |
| Spanishburg | city | West Virginia | United States | 37.45 | -81.12 | 2509 | |
| Sparks (historical) | city | West Virginia | United States | 38.24 | -80.90 | 1669 | |
| Spaulding | city | West Virginia | United States | 37.88 | -82.35 | 925 | |
| Spears (historical) | city | West Virginia | United States | 38.12 | -82.12 | 944 | |
| Speed | city | West Virginia | United States | 38.73 | -81.38 | 898 | |
| Speedway | city | West Virginia | United States | 37.46 | -81.01 | 2618 | |
| Spelter | city | West Virginia | United States | 39.35 | -80.32 | 1240 | |
| Spencer | city | West Virginia | United States | 38.80 | -81.35 | 974 | |
| Spice | city | West Virginia | United States | 38.11 | -80.27 | 2723 | |
| Spohrs Crossroads | city | West Virginia | United States | 39.63 | -78.15 | 830 | |
| Sprague | city | West Virginia | United States | 37.79 | -81.18 | 2509 | |
| Sprattsville | city | West Virginia | United States | 37.60 | -81.87 | 1102 | |
| Spread | city | West Virginia | United States | 38.50 | -81.07 | 1099 | |
| Sprigg | city | West Virginia | United States | 37.63 | -82.20 | 1108 | |
| Spring Creek | city | West Virginia | United States | 37.95 | -80.35 | 1965 | |
| Spring Dale | city | West Virginia | United States | 37.88 | -80.80 | 2795 | |
| Spring Gap (historical) | city | West Virginia | United States | 39.42 | -78.53 | 1105 | |
| Spring Hill | city | West Virginia | United States | 38.35 | -81.73 | 830 | |
| Spring Hill Chapel | city | West Virginia | United States | 39.24 | -80.37 | 1151 | |
| Spring Mills | city | West Virginia | United States | 39.56 | -77.95 | 830 | |
| Spring Run | city | West Virginia | United States | 39.43 | -81.17 | 830 | |
| Spring Valley | city | West Virginia | United States | 38.39 | -82.52 | 898 | |
| Springdale | city | West Virginia | United States | 40.06 | -80.65 | 1062 | |
| Springdale Estates | city | West Virginia | United States | 38.45 | -81.99 | 830 | |
| Springfield | city | West Virginia | United States | 39.45 | -78.69 | 830 | |
| Springlea Estates | city | West Virginia | United States | 38.47 | -81.86 | 898 | |
| Springton | city | West Virginia | United States | 37.46 | -81.24 | 2539 | |
| Sproul | city | West Virginia | United States | 38.25 | -81.80 | 830 | |
| Spruce | city | West Virginia | United States | 38.46 | -79.96 | 4189 | |
| Spruce Valley | city | West Virginia | United States | 37.88 | -81.82 | 1669 | |
| Spurgeon | city | West Virginia | United States | 39.10 | -80.78 | 997 | |
| Spurlockville | city | West Virginia | United States | 38.13 | -82.02 | 830 | |
| Spy Rock | city | West Virginia | United States | 38.07 | -80.98 | 2509 |