| Name | What | Region | Country | Lat | Long | Elev ft. | Pop est |
|---|---|---|---|---|---|---|---|
| Clambank | city | South Carolina | United States | 33.34 | -79.19 | 3 | |
| Claremont | city | South Carolina | United States | 33.97 | -80.56 | 127 | |
| Clarendon | city | South Carolina | United States | 34.55 | -82.63 | 830 | |
| Clark Estates | city | South Carolina | United States | 35.11 | -82.04 | 830 | |
| Clarks Crossroads | city | South Carolina | United States | 33.80 | -79.82 | 68 | |
| Clarks Hill | city | South Carolina | United States | 33.67 | -82.17 | 403 | |
| Clarks Point | city | South Carolina | United States | 32.74 | -79.95 | 6 | |
| Clarks Sound | city | South Carolina | United States | 32.72 | -79.94 | 3 | |
| Clarkson (historical) | city | South Carolina | United States | 34.79 | -81.33 | 830 | |
| Clatworthy Crossroads | city | South Carolina | United States | 34.06 | -82.37 | 830 | |
| Claussen | city | South Carolina | United States | 34.13 | -79.63 | 78 | |
| Clayton | city | South Carolina | United States | 34.49 | -81.42 | 400 | |
| Clear Pond | city | South Carolina | United States | 33.19 | -81.03 | 147 | |
| Clear Springs | city | South Carolina | United States | 34.12 | -80.93 | 351 | |
| Clearmont | city | South Carolina | United States | 34.67 | -83.06 | 846 | |
| Clearview | city | South Carolina | United States | 34.53 | -82.73 | 830 | |
| Clearview Heights | city | South Carolina | United States | 35.04 | -81.99 | 898 | |
| Clearview Heights | city | South Carolina | United States | 35.00 | -81.87 | 830 | |
| Clearwater | city | South Carolina | United States | 33.50 | -81.89 | 147 | |
| Cleland Crossroads | city | South Carolina | United States | 32.94 | -81.12 | 108 | |
| Clementia (historical) | city | South Carolina | United States | 32.73 | -80.19 | 3 | |
| Clemson | city | South Carolina | United States | 34.68 | -82.84 | 830 | |
| Clemson Forest | city | South Carolina | United States | 34.67 | -82.88 | 830 | |
| Clemson Gardens | city | South Carolina | United States | 34.68 | -82.81 | 830 | |
| Clemson Heights | city | South Carolina | United States | 34.66 | -82.84 | 830 | |
| Clemson Terrace | city | South Carolina | United States | 33.05 | -80.20 | 75 | |
| Cleora | city | South Carolina | United States | 33.84 | -82.05 | 383 | |
| Clevedale | city | South Carolina | United States | 34.93 | -82.04 | 830 | |
| Cleveland | city | South Carolina | United States | 35.07 | -82.53 | 1020 | |
| Cleveland Forest | city | South Carolina | United States | 34.84 | -82.39 | 898 | |
| Cleveland-A-Farm | city | South Carolina | United States | 34.64 | -82.95 | 830 | |
| Clifton | city | South Carolina | United States | 34.98 | -81.82 | 830 | |
| Clifton Station | city | South Carolina | United States | 35.00 | -81.82 | 830 | |
| Climax | city | South Carolina | United States | 34.07 | -81.46 | 400 | |
| Clinton | city | South Carolina | United States | 34.47 | -81.88 | 830 | |
| Clinton Park | city | South Carolina | United States | 34.91 | -81.06 | 830 | |
| Clio | city | South Carolina | United States | 34.58 | -79.55 | 167 | |
| Cloisters | city | South Carolina | United States | 34.70 | -80.81 | 830 | |
| Cloisters | city | South Carolina | United States | 34.15 | -79.78 | 114 | |
| Clover | city | South Carolina | United States | 35.11 | -81.23 | 830 | |
| Clover Hill | city | South Carolina | United States | 34.45 | -82.63 | 830 | |
| Cloverdale | city | South Carolina | United States | 34.48 | -82.70 | 830 | |
| Cloverleaf Mobile Home Park | city | South Carolina | United States | 33.04 | -80.16 | 55 | |
| Clovis Point | city | South Carolina | United States | 34.73 | -82.95 | 830 | |
| Club Acres | city | South Carolina | United States | 33.51 | -80.88 | 200 | |
| Club Colony | city | South Carolina | United States | 34.39 | -80.09 | 200 | |
| Club Forest | city | South Carolina | United States | 33.90 | -80.37 | 144 | |
| Club Forest | city | South Carolina | United States | 34.82 | -82.40 | 889 | |
| Clubhouse Crossroads | city | South Carolina | United States | 33.96 | -81.40 | 830 | |
| Clubhouse Crossroads | city | South Carolina | United States | 32.90 | -80.32 | 29 | |
| Clubside Estates | city | South Carolina | United States | 34.88 | -81.04 | 830 | |
| Clyburn | city | South Carolina | United States | 34.42 | -80.60 | 298 | |
| Clyde | city | South Carolina | United States | 34.39 | -80.18 | 246 |