| IATA | Name | City | Distance | Airline(s) |
| DAV | ENRIQUE MALEK INTL | David | 185 nm | Copa Airlines |
| CTG | RAFAEL NUNEZ | Cartagena | 243 nm | Copa Airlines, Copa Airlines Colombia |
| ADZ | GUSTAVO ROJAS PINILLA | San Andres I | 251 nm | Copa Airlines, Copa Airlines Colombia |
| SJO | JUAN SANTAMARIA INTL | San Jose | 290 nm | Avianca Costa Rica, Copa Airlines, Copa Airlines Colombia, FedEx Express |
| BAQ | ERNESTO CORTISSOZ | Barranquilla | 293 nm | Copa Airlines Colombia |
| MDE | JOSE MARIA CORDOVA | Rionegro | 293 nm | Copa Airlines Colombia |
| PEI | MATECANA | Pereira | 335 nm | Copa Airlines Colombia |
| LIR | DANIEL ODUBER QUIROS INTL | Liberia | 375 nm | Copa Airlines |
| CLO | ALFONSO BONILLA ARAGON INTL | Cali | 376 nm | Copa Airlines Colombia |
| BGA | PALONEGRO | Bucaramanga | 386 nm | Copa Airlines Colombia |
| BOG | ELDORADO INTL | Bogota | 407 nm | AeroSucre S.A., Avianca, Avianca Ecuador, Copa Airlines, Copa Airlines Colombia, LÃneas Aéreas Suramericanas - LAS Cargo |
| CUC | CAMILO DAZA | Cucuta | 413 nm | Copa Airlines Colombia |
| MGA | MANAGUA INTL | Managua | 440 nm | Copa Airlines |
| MAR | LA CHINITA INTL | Maracaibo | 461 nm | Avior Airlines, Copa Airlines, Venezolana |
| TGU | TONCONTIN INTL | Tegucialpa | 549 nm | Copa Airlines |
| KIN | NORMAN MANLEY INTL | Kingston | 552 nm | Copa Airlines |
| UIO | Mariscal Sucre International Airport | Quito | 555 nm | Avianca Ecuador, Copa Airlines, Copa Airlines Colombia |
| MBJ | SANGSTER INTL | Montego Bay | 572 nm | Copa Airlines |
| AUA | REINA BEATRIX INTL | Oranjestad | 589 nm | Aruba Airlines, Copa Airlines, DHL Aero Expreso |
| SAL | EL SALVADOR INTL | San Salvador | 626 nm | Copa Airlines, TACA Airlines |
| SAP | LA MESA INTL | San Pedro Sula | 630 nm | Copa Airlines, Copa Airlines Colombia |
| CUR | HATO | Willemstad | 642 nm | Copa Airlines, DHL Aero Expreso |
| GYE | JOSE JOAQUIN DE OLMEDO INTL | Guayaquil | 674 nm | Copa Airlines, Copa Airlines Colombia |
| VLN | ARTURO MICHELENA INTL | Valencia | 680 nm | Avior Airlines, Copa Airlines |
| PAP | TOUSSAINT LOUVERTURE INTL | Port-au-Prince | 704 nm | Copa Airlines |
| HOG | FRANK PAIS INTL | Holguin | 724 nm | Copa Airlines |
| BZE | PHILIP S W GOLDSON INTL | Belize | 727 nm | Copa Airlines |
| GUA | LA AURORA | Guatemala City | 732 nm | Aero Express del Ecuador, Copa Airlines, Copa Airlines Colombia |
| CCS | SIMON BOLIVAR INTL | Maiquetia | 738 nm | Avior Airlines, Consorcio Venezolano de Industrias Aeronáuticas y Servicios Aéreos, Copa Airlines, LASER Airlines , SBA Airlines, Venezolana, Vensecar Internacional Compañia Anonima |
| SDQ | LAS AMERICAS INTL | Santo Domingo | 796 nm | Copa Airlines |
| STI | CIBAO INTL | Santiago | 802 nm | Copa Airlines Colombia |
| SNU | ABEL SANTAMARIA | Santa Clara | 805 nm | Copa Airlines |
| CUN | CANCUN INTL | Cancún | 838 nm | Copa Airlines |
| HAV | JOSE MARTI INTL | Havana | 852 nm | Copa Airlines |
| PUJ | PUNTA CANA INTL | Higuey | 857 nm | Copa Airlines, Copa Airlines Colombia |
| BLA | GENERAL JOSE ANTONIO ANZOATEGUI INTL | Barcelona | 871 nm | Avior Airlines |
| CIX | CAPT JOSE A QUINONES GONZALES INTL | Chiclayo | 951 nm | Copa Airlines |
| SJU | LUIS MUNOZ MARIN INTL | San Juan | 960 nm | Copa Airlines |
| NAS | LYNDEN PINDLING INTL | Nassau | 964 nm | Copa Airlines |
| MIA | MIAMI INTL | MIAMI | 1004 nm | American Airlines, Inc., American Eagle, Amerijet International, Copa Airlines, LATAM Cargo Colombia, Transportes Aéreos Bolivianos, UPS Airlines |
| FLL | FORT LAUDERDALE HOLLYWOOD INTL | FORT LAUDERDALE | 1021 nm | Copa Airlines, Spirit Airlines |
| POS | PIARCO | Port of Spain | 1070 nm | Copa Airlines |
| SXM | PRINCESS JULIANA INTL | Philipsburg | 1090 nm | Copa Airlines |
| TPA | TAMPA INTL | TAMPA | 1148 nm | Copa Airlines |
| MCO | ORLANDO INTL | ORLANDO | 1166 nm | Copa Airlines |
| GEO | CHEDDI JAGAN INTL | Georgetown | 1265 nm | Copa Airlines |
| Jorge Chávez International Airport | | 1272 nm | Copa Airlines |
| MEX | LICENCIADO BENITO JUAREZ INTL | Mexico City | 1300 nm | AeroMéxico, Copa Airlines, LATAM Cargo México |
| MAO | EDUARDO GOMES INTL | Manaus | 1365 nm | Copa Airlines |
| MSY | LOUIS ARMSTRONG NEW ORLEANS INTL | New Orleans | 1395 nm | Copa Airlines |
| ATL | HARTSFIELD JACKSON ATLANTA INTL | Atlanta | 1500 nm | Delta Air Lines, Inc. |
| IAH | GEORGE BUSH INTCNTL HOUSTON | Houston | 1541 nm | United Airlines, Inc. |
| GDL | DON MIGUEL HIDALGO Y COSTILLA INTL | Guadalajara | 1545 nm | Copa Airlines, LATAM Cargo México |
| MTY | GENERAL MARIANO ESCOBEDO INTL | Monterrey | 1548 nm | Copa Airlines |
| DFW | DALLAS FORT WORTH INTL | DALLAS-FORT WORTH | 1732 nm | American Airlines, Inc. |
| SDF | LOUISVILLE INTL STANDIFORD FLD | LOUISVILLE | 1779 nm | UPS Airlines |
| IAD | WASHINGTON DULLES INTL | WASHINGTON | 1795 nm | Copa Airlines |
| VVI | VIRU VIRU INTL | Santa Cruz | 1870 nm | Copa Airlines, Transportes Aéreos Bolivianos |
| EWR | NEWARK LIBERTY INTL | NEWARK | 1917 nm | United Airlines, Inc. |
| JFK | JOHN F KENNEDY INTL | New York | 1917 nm | Copa Airlines |
| ORD | CHICAGO OHARE INTL | CHICAGO | 2025 nm | Copa Airlines |
| BOS | GENERAL EDWARD LAWRENCE LOGAN INTL | Boston | 2045 nm | Copa Airlines |
| YYZ | LESTER B PEARSON INTL | Toronto | 2076 nm | Air Transat, Copa Airlines, Sunwing Airlines, http://en.wikipedia.org/wiki/Air_Canada_Rouge |
| YUL | PIERRE ELLIOTT TRUDEAU INTL | Montreal | 2203 nm | Copa Airlines, Sunwing Airlines |
| DEN | DENVER INTL | DENVER | 2288 nm | United Airlines, Inc. |
| BSB | PRESIDENTE JUSCELINO KUBITSCHEK | Brasilia | 2394 nm | Copa Airlines |
| ASU | SILVIO PETTIROSSI INTL | Asuncion | 2422 nm | Copa Airlines |
| LAS | MC CARRAN INTL | Las Vegas | 2534 nm | Copa Airlines |
| FOR | PINTO MARTINS INTL | Fortaleza | 2561 nm | |
| COR | AMBROSIO L V TARAVELLA | Cordoba | 2575 nm | Copa Airlines |
| SCL | ARTURO MERINO BENITEZ INTL | Santiago | 2594 nm | Copa Airlines |
| LAX | LOS ANGELES INTL | LOS ANGELES | 2614 nm | Copa Airlines |
| CNF | TANCREDO NEVES INTL | Belo Horizonte | 2710 nm | Copa Airlines |
| ROS | ROSARIO | Rosario | 2733 nm | Copa Airlines |
| GRU | GUARULHOS GOV ANDRE FRANCO MONTOURO | Sao Paulo | 2744 nm | Copa Airlines |
| REC | GUARARAPES GILBERTO FREYRE INTL | Recife | 2850 nm | Copa Airlines |
| POA | SALGADO FILHO | Porto Alegre | 2853 nm | Copa Airlines |
| GIG | GALEAO ANTONIO CARLOS JOBIM | Rio De Janeiro | 2857 nm | Copa Airlines |
| SFO | SAN FRANCISCO INTL | SAN FRANCISCO | 2883 nm | Copa Airlines |
| EZE | MINISTRO PISTARINI | Buenos Aires | 2887 nm | Copa Airlines |
| MVD | CARRASCO INTL | Montevideo | 2949 nm | Copa Airlines |
| MAD | BARAJAS | Madrid | 4401 nm | Iberia, Plus Ultra LÃneas Aéreas |
| CDG | CHARLES DE GAULLE | Paris | 4673 nm | Société Air France, S.A. |
| AMS | SCHIPHOL | Amsterdam | 4755 nm | KLM |
| FRA | FRANKFURT MAIN | Frankfurt-am-Main | 4904 nm | Condor, Deutsche Lufthansa AG |
| IST | ATATURK | Istanbul | 5846 nm | Turkish Airlines |